DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q9JWM8_2001222 MC39389 A0A4V3D5C5_39389 4-128 1-125 0.87 1.0 0.86 0.99 0.99 0.94 75.2
Q8DQ62_2000279 MC3938 A0A343JA54_3938 5-199 2-192 0.84 1.0 0.76 0.91 0.91 0.85 34.8
O97193_2001057 MC39237 A0A504XRD0_39237 16-329 1-314 0.95 1.0 0.95 1.0 1.0 0.96 97.4
P13620_2001006 MC39212 A0A482XEE2_39212 5-115 9-120 0.92 0.7 0.81 0.63 0.63 0.91 28.5
Q9NXG2_2000836 MC39188 F7FA68_39188 1-85 36-120 1.0 0.63 1.0 0.63 0.63 1.0 94.1
O04708_2000893 MC39175 A0A3Q7JWY0_39175 1-198 46-247 1.0 0.82 1.0 0.8 0.8 0.99 81.1
O31562_2000794 MC39165 A0A2W0CYC1_39165 9-170 1-162 0.93 1.0 0.92 0.99 0.99 0.92 51.2
O34498_2000329 MC39140 A0A7W7PY98_39140 8-66 3-67 0.84 0.28 0.48 0.19 0.19 0.64 9.0
Q9CR50_2001132 MC39135 A0A2V3J0U0_39135 6-74 13-83 0.93 0.73 0.89 0.69 0.69 0.92 39.4
Q87LT3_2001226 MC39123 A0A090P4B6_39123 1-67 16-82 1.0 0.82 0.97 0.79 0.79 0.95 71.6
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.