DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P30047_2000579 MC40069 A0A674C2Y0_40069 1-84 2-85 1.0 0.98 0.99 0.97 0.97 0.99 60.7
R4YEY9_2001271 MC4003 A0A7G2INX0_4003 1-35 15-49 1.0 0.11 1.0 0.11 0.11 1.0 100.0
R4YEY9_2000000 MC4003 A0A6N8Q492_4003 1-49 208-256 1.0 0.18 1.0 0.18 0.18 1.0 97.9
P13276_2000398 MC40009 A0A1I2IE86_40009 12-150 9-147 0.84 0.94 0.53 0.57 0.57 0.49 13.1
Q9BV81_2001580 MC400 A0A1B0CM13_400 1-81 13-93 1.0 0.87 0.95 0.83 0.83 0.93 69.1
O24876_2000295 MC39927 J0QIH3_39927 1-92 1-92 1.0 0.99 0.97 0.96 0.96 0.96 93.4
P41594_2000620 MC39888 A0A3P9DMP6_39888 1-56 100-155 1.0 0.33 0.99 0.33 0.33 0.99 87.5
P20434_2001058 MC39682 A0A1X7SQC7_39682 1-72 13-84 1.0 0.81 0.99 0.81 0.81 1.0 68.0
Q97PK0_2000702 MC39663 A0A0R2FPC1_39663 7-265 2-326 0.98 1.0 0.93 0.76 0.76 0.85 32.9
Q6NW40_2001649 MC39459 A0A2H6NFF8_39459 1-153 5-157 1.0 0.64 1.0 0.64 0.64 0.99 89.5
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.