DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P26902_2000495 MC43305 A0A4Q3KF93_43305 1-247 1-247 0.9 1.0 0.87 0.96 0.96 0.81 31.0
P54278_2000066 MC43139 F1NQJ3_43139 1-203 20-222 1.0 0.7 1.0 0.7 0.7 1.0 82.7
Q6EVP2_2000970 MC43110 A0A7S0E8P8_43110 3-277 2-153 0.98 0.97 0.38 0.64 0.64 0.55 9.4
W5PJ73_2001129 MC43084 A0A1Q7JBZ6_43084 40-385 1-346 0.89 1.0 0.89 0.99 0.99 0.89 41.6
Q9QYJ6_2000597 MC43040 A0A1S3Q7C1_43040 1-308 25-332 1.0 0.89 1.0 0.89 0.89 0.99 78.5
A0A1S3UIW7_2000560 MC43038 A0A103XKJ7_43038 1-83 32-114 1.0 0.66 0.99 0.66 0.66 1.0 83.1
B7LAK9_2000737 MC43033 A0A485C186_43033 1-92 5-96 1.0 0.96 1.0 0.95 0.95 0.99 81.5
Q9QWW1_2000118 MC43020 A0A485N8M8_43020 1-109 1-109 1.0 0.81 1.0 0.81 0.81 1.0 98.1
P46075_2001207 MC4301 A0A3F3R886_4301 1-149 49-197 1.0 0.72 1.0 0.72 0.72 1.0 74.4
O46162_2000365 MC42832 A0A5E4CRV2_42832 5-35 68-98 0.89 0.18 0.81 0.18 0.18 0.86 41.9
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.