DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q9JLV5_2000144 MC44051 A0A6J0HTG9_44051 1-71 121-191 1.0 0.37 1.0 0.37 0.37 1.0 100.0
Q45581_2000143 MC44051 A0A1H0B0R3_44051 1-45 10-56 0.96 0.22 0.73 0.19 0.19 0.71 17.0
Q9H814_2001269 MC44001 L9LDN6_44001 1-85 67-151 0.99 0.54 0.99 0.54 0.54 0.99 92.9
A0A045H4J2_2000837 MC43893 A0A522NFG0_43893 1-59 3-61 1.0 0.91 1.0 0.91 0.91 1.0 93.2
P11387_2001112 MC43883 A0A177AWQ5_43883 1-229 25-253 1.0 0.9 0.99 0.9 0.9 0.98 65.5
Q8EEA0_2000272 MC43836 A0A0A2VCR2_43836 46-417 1-372 0.89 0.72 0.89 0.71 0.71 0.93 69.6
P0A4T9_2000902 MC43661 A0A848XD13_43661 1-92 30-121 0.98 0.76 0.96 0.75 0.75 0.94 38.0
Q13261_2000565 MC4358 Q13261_4358 1-78 31-108 1.0 0.56 1.0 0.56 0.56 1.0 100.0
P04050_2000716 MC4357 A0A0G4NF65_4357 1-147 120-266 1.0 0.44 1.0 0.44 0.44 1.0 78.9
Q15257_2001224 MC43561 A0A507CF31_43561 1-334 1-299 0.99 1.0 0.88 0.99 0.99 0.92 46.1
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.