DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P01130_2000469 MC42832 A0A3B3UHI7_42832 1-36 53-88 1.0 0.21 0.98 0.21 0.21 0.99 63.8
P87126_2001070 MC42700 L7HXX5_42700 1-23 91-113 1.0 0.12 0.99 0.12 0.12 1.0 69.5
Q9Z2D7_2000568 MC42687 A0A2P6VLS1_42687 6-137 1-132 0.92 0.99 0.9 0.97 0.97 0.89 46.2
Q9RXJ5_2000538 MC42658 A0A535X2M7_42658 7-131 1-125 0.92 1.0 0.91 0.99 0.99 0.94 60.0
Q8TDZ2_2001531 MC42334 A0A5F8HKQ5_42334 2-142 11-151 0.99 0.92 0.97 0.91 0.91 0.98 73.7
Q08AE8_2001449 MC42223 T2IGP8_42223 3-171 85-274 0.84 0.65 0.52 0.37 0.37 0.59 9.5
O75460_2001405 MC42223 A0A835H308_42223 2-115 226-342 0.88 0.34 0.66 0.28 0.28 0.55 21.6
Q96L34_2000046 MC42223 A0A817VUA1_42223 1-262 16-277 1.0 0.82 1.0 0.82 0.82 1.0 87.7
P52657_2001152 MC42143 A0A210PQB4_42143 1-51 3-53 1.0 0.93 1.0 0.93 0.93 1.0 80.3
P0ABA4_2000460 MC4202 A0A317MVP2_4202 8-103 2-104 0.91 0.59 0.88 0.53 0.53 0.87 30.0
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.