DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q7PP01_2000571 MC44506 A0A5E4NGM6_44506 2-179 34-212 0.99 0.8 0.99 0.79 0.79 0.97 68.7
P59768_2001080 MC44483 A0A6P6L912_44483 1-60 20-79 1.0 0.7 0.99 0.69 0.69 1.0 95.0
Q9X298_2000531 MC44406 W4QJ19_44406 4-126 7-74 0.98 0.92 0.35 0.54 0.54 0.52 10.4
Q9KMK9_2000410 MC44399 A0A1H0WNI2_44399 2-155 10-162 0.99 0.93 0.97 0.92 0.92 0.95 50.0
P29396_2000703 MC44385 A0A4Y7KHR3_44385 1-30 1-30 1.0 0.23 0.9 0.23 0.23 0.97 20.0
Q9A5I0_2000594 MC44385 B1ZAW5_44385 1-84 19-102 1.0 0.82 1.0 0.82 0.82 1.0 78.5
P25491_2000556 MC44383 J4H541_44383 2-80 249-327 0.99 0.22 0.97 0.22 0.22 0.94 49.3
Q7CRW4_2000360 MC44304 A0A1I5UF36_44304 4-299 3-299 0.85 0.99 0.84 0.98 0.98 0.89 58.5
Q7CR17_2000890 MC44298 J7QY06_44298 1-68 13-80 1.0 0.85 1.0 0.85 0.85 1.0 100.0
Q8ZNH1_2000109 MC44191 A0A6C8H0H3_44191 1-121 2-122 1.0 0.85 1.0 0.85 0.85 1.0 100.0
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.