DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P02712_2000933 MC49481 A0A4Z2BDR6_49481 1-248 142-418 0.99 0.66 0.74 0.44 0.44 0.82 40.2
P82245_2001216 MC4946 A0A4D8Y911_4946 2-74 33-105 0.99 0.68 0.98 0.67 0.67 0.99 90.4
H0USY9_2001427 MC4943 A0A6S6QGE8_4943 2-93 25-117 0.99 0.8 0.57 0.48 0.48 0.56 16.6
Q47PI4_2001355 MC4940 A0A2M9M8Q0_4940 3-410 1-331 0.99 0.92 0.74 0.84 0.84 0.72 42.1
P49771_2001054 MC49339 G1QZC3_49339 2-134 27-159 0.99 0.65 0.99 0.65 0.65 1.0 99.2
Q1LK00_2001200 MC49322 A0A223RSM8_49322 6-262 54-310 0.97 0.83 0.9 0.77 0.77 0.82 39.6
P64201_2000919 MC49317 A0A166H2K9_49317 1-107 287-392 1.0 0.25 0.96 0.25 0.25 0.89 41.1
Q56219_2000679 MC49280 A0A2V5WR90_49280 5-161 2-150 0.8 0.92 0.67 0.8 0.8 0.75 29.7
A0A045JER3_2000439 MC49277 A0A6I3ASG9_49277 1-85 1-85 1.0 0.88 1.0 0.87 0.87 1.0 65.8
P35558_2001096 MC49215 A0A151M4Q4_49215 2-237 1-237 1.0 0.77 0.99 0.77 0.77 0.98 72.9
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.