DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q5SIT3_2001596 MC49215 A0A061NRV6_49215 2-66 53-119 0.94 0.49 0.48 0.29 0.29 0.6 18.3
Q08687_2001521 MC492 A0A1Y2HUD4_492 2-130 17-145 0.92 0.79 0.78 0.68 0.68 0.8 21.0
Q5RKV6_2000271 MC49063 A0A6P6HM20_49063 1-95 75-169 1.0 0.56 0.99 0.55 0.55 0.98 92.6
Q9NPA8_2001302 MC49010 A0A437CVD9_49010 1-90 2-91 0.99 0.96 0.98 0.94 0.94 0.98 86.6
Q9UHL9_2000728 MC490 A0A485P0Z2_490 2-86 25-109 0.99 0.4 0.96 0.39 0.39 0.98 98.8
P39805_2000001 MC48898 R6QN42_48898 1-54 1-54 0.98 0.79 0.96 0.78 0.78 0.95 50.0
P35844_2000286 MC48846 A0A075AR06_48846 11-358 7-331 0.8 0.97 0.72 0.93 0.93 0.76 38.2
O58562_2001598 MC4878 A0A497M6K0_4878 1-97 39-151 0.99 0.74 0.81 0.54 0.54 0.7 18.2
Q5ZXQ9_2000254 MC48502 A0A535DN09_48502 30-247 2-215 0.87 0.97 0.79 0.89 0.89 0.77 18.7
Q9ZVQ3_2000244 MC48412 W9RY40_48412 1-133 88-220 1.0 0.6 0.98 0.59 0.59 0.95 55.6
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.