DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q8PRU3_2000973 MC49914 A0A2E8HNB1_49914 4-162 2-159 0.86 0.99 0.83 0.96 0.96 0.84 42.7
Q5W9E8_2001279 MC49903 A0A1M2V9M8_49903 2-171 1-172 0.96 1.0 0.94 0.97 0.97 0.91 51.1
W8L932_2000184 MC49828 A0A5P1FIR8_49828 1-41 22-62 0.95 0.31 0.77 0.28 0.28 0.89 9.7
P43961_2001340 MC49792 A0A1E4FBP0_49792 17-120 3-96 0.83 0.97 0.62 0.77 0.77 0.65 12.5
G3MM57_2001318 MC49775 A0A4D5RXA1_49775 2-287 22-307 1.0 0.79 0.99 0.79 0.79 0.98 76.2
P30904_2001087 MC4976 A0A091CZQ6_4976 2-103 12-113 0.99 0.86 0.99 0.85 0.85 0.98 89.2
P9WJ71_2001526 MC49616 A0A5A7SE04_49616 5-47 32-74 0.92 0.19 0.82 0.18 0.18 0.86 30.2
P69380_2001056 MC49595 A0A2V2GIG9_49595 2-203 3-217 0.99 0.73 0.94 0.66 0.66 0.84 31.1
Q7SIC7_2000198 MC49535 A0A5M3XYU9_49535 2-333 7-429 1.0 0.98 0.96 0.75 0.75 0.87 40.4
J7JGR6_2000282 MC49481 J9PBR5_49481 27-205 1-179 0.87 1.0 0.87 1.0 1.0 0.92 100.0
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.