DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
A3MW14_2001292 MC49965 T1AS66_49965 1-51 5-56 1.0 0.88 0.93 0.81 0.81 0.95 46.1
Q9Z4J7_2001061 MC49953 A0A1H3NS81_49953 52-540 1-306 0.84 1.0 0.46 0.85 0.85 0.52 16.6
Q04724_2001013 MC49953 A0A671VWR0_49953 20-321 1-302 0.9 1.0 0.9 1.0 1.0 0.93 95.6
P30617_2001063 MC49953 A0A2I0VLD6_49953 2-106 110-214 0.97 0.49 0.93 0.48 0.48 0.94 45.7
Q9UH77_2000982 MC49953 A0A7R9KHP5_49953 7-286 1-281 0.98 0.98 0.97 0.97 0.97 0.94 64.4
G2QVH2_2000972 MC49953 C4RF49_49953 1-299 9-309 0.99 0.97 0.99 0.96 0.96 0.97 75.4
P39900_2000959 MC49953 A0A7J5YFL5_49953 9-192 1-181 0.95 0.9 0.91 0.88 0.88 0.87 36.4
Q58AD3_2001599 MC49953 A0A0F6SH54_49953 5-62 104-174 0.88 0.28 0.53 0.16 0.16 0.58 9.7
Q99523_2001276 MC49953 F0LMV2_49953 77-514 5-282 0.84 0.98 0.31 0.51 0.51 0.36 8.5
B6A880_2001584 MC49953 Q5EK49_49953 17-314 12-312 0.92 0.96 0.66 0.68 0.68 0.55 12.3
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.