DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q15545_2000124 MC51031 A0A5F8HE96_51031 1-144 2-145 1.0 0.73 0.96 0.7 0.7 0.96 90.2
P45573_2000549 MC51027 A0A3A4NHP6_51027 1-97 1-97 0.94 1.0 0.91 0.97 0.97 0.88 32.9
P18064_2000428 MC51017 A0A2R6W8M0_51017 1-124 311-455 1.0 0.3 0.88 0.24 0.24 0.74 24.1
Q9UM07_2000557 MC51005 A0A0Q3T7D7_51005 2-109 5-115 0.99 0.36 0.86 0.32 0.32 0.81 33.3
Q9KX51_2001330 MC50909 A0A445EPA2_50909 7-152 49-170 0.92 0.7 0.39 0.36 0.36 0.51 8.2
P0C6E0_2000323 MC50806 A0A182TB27_50806 1-111 12-122 1.0 0.86 1.0 0.86 0.86 0.99 71.1
P49327_2000715 MC50758 A0A2W1BJ46_50758 2-112 60-170 0.99 0.61 0.98 0.61 0.61 0.98 49.5
P41088_2000510 MC50697 A0A4Y1R1J3_50697 12-210 1-199 0.93 1.0 0.93 0.99 0.99 0.94 71.8
Q9HT79_2001527 MC50524 A0A014PHG1_50524 10-74 40-113 0.87 0.34 0.54 0.2 0.2 0.63 6.7
Q9KZL7_2000257 MC50431 A0A3D4P1F2_50431 10-55 1-46 0.82 0.96 0.72 0.83 0.83 0.83 35.4
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.