DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q9K0R7_2000533 MC51628 E3FFW7_51628 13-119 3-105 0.82 0.95 0.51 0.6 0.6 0.49 13.1
Q48152_2000070 MC51609 A0A852PTJ0_51609 1-77 41-117 1.0 0.66 0.99 0.65 0.65 0.98 50.6
U3KMN4_2000512 MC51471 A0A7R9GBP4_51471 38-191 1-154 0.81 1.0 0.8 1.0 1.0 0.91 94.8
Q99P87_2000196 MC51379 A0A3P7FT65_51379 1-87 1-78 0.98 0.61 0.48 0.36 0.36 0.6 5.2
Q97F93_2001304 MC51316 A0A7X9GCB6_51316 1-57 4-60 1.0 0.95 0.99 0.94 0.94 0.99 64.9
Q57DF0_2000476 MC51299 D0RHH0_51299 1-76 8-83 1.0 0.87 1.0 0.87 0.87 1.0 98.6
Q837A3_2001362 MC51229 A0A1J6YK85_51229 1-165 4-168 0.96 0.98 0.96 0.98 0.98 0.96 100.0
P32969_2000465 MC51111 L8IEB5_51111 1-87 1-87 1.0 0.53 0.99 0.53 0.53 0.99 96.5
Q8ZG78_2001644 MC5108 A0A1Q9D648_5108 6-79 40-112 0.86 0.3 0.41 0.18 0.18 0.53 13.3
Q7MVF6_2001092 MC5107 A0A7Z9JXS8_5107 12-132 4-128 0.92 0.98 0.74 0.77 0.77 0.72 17.1
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.