DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q9K6M5_2000487 MC50424 A0A5C0WMF3_50424 3-140 2-141 0.84 0.99 0.76 0.88 0.88 0.72 27.6
Q00459_2000433 MC50349 Q479D6_50349 1-89 11-99 0.97 0.9 0.95 0.89 0.89 0.95 59.5
Q9ZCQ4_2000963 MC50275 A0A3F2S0B6_50275 19-449 1-433 0.95 1.0 0.94 0.99 0.99 0.93 62.3
P30130_2000639 MC5022 A0A376NZI9_5022 15-121 1-107 0.88 0.91 0.87 0.89 0.89 0.95 96.2
P39678_2000497 MC50204 A0A376BBP9_50204 1-99 1-99 1.0 0.62 1.0 0.62 0.62 1.0 78.7
P70475_2000342 MC50077 A0A6J3Q4B0_50077 1-48 20-67 1.0 0.46 0.95 0.44 0.44 0.97 95.8
Q9C932_2000201 MC5005 A0A7G2EMR5_5005 11-163 154-308 0.94 0.45 0.88 0.43 0.43 0.86 50.9
Q42521_2000607 MC5005 A0A7G2ER20_5005 41-433 1-393 0.9 1.0 0.9 1.0 1.0 0.99 82.6
Q9HZJ8_2001259 MC5005 D2VZL8_5005 13-117 65-178 0.88 0.31 0.62 0.23 0.23 0.54 10.2
P36683_2000932 MC50032 A0A812RLG3_50032 9-404 1-331 0.81 1.0 0.63 0.93 0.93 0.71 61.3
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.