DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P63883_2001493 MC9301 A0A0H3L6K5_9301 2-111 18-127 0.99 0.75 0.98 0.75 0.75 0.98 63.6
Q00987_2000236 MC9233 A0A6J0CZD1_9233 1-85 20-104 1.0 0.66 1.0 0.66 0.66 1.0 95.2
Q8YQN0_2000252 MC9193 A0A2L2NTG4_9193 1-86 23-108 1.0 0.78 1.0 0.78 0.78 0.99 76.7
P05630_2000172 MC9135 A0A341AZ32_9135 1-87 1-87 1.0 0.72 0.99 0.72 0.72 0.99 96.5
Q74H32_2001592 MC9039 A0A820UXY7_9039 9-133 62-165 0.94 0.63 0.46 0.37 0.37 0.53 4.8
Q16790_2001023 MC9038 A0A7J7EJA9_9038 1-255 5-311 1.0 0.97 1.0 0.8 0.8 0.99 74.9
Q06811_2001448 MC9009 A0A0N5A8H8_9009 3-122 6-122 0.93 0.71 0.34 0.28 0.28 0.51 12.8
P43572_2001381 MC8944 W6MLK9_8944 1-142 110-254 1.0 0.34 0.9 0.31 0.31 0.8 43.5
P43572_2000103 MC8944 W6MLK9_8944 1-63 283-345 1.0 0.14 0.98 0.15 0.15 1.0 44.4
Q9JZC8_2000224 MC8929 A0A1A9WVW9_8929 2-166 156-320 0.98 0.5 0.89 0.47 0.47 0.86 42.4
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.