DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P0AET2_2000330 MC958 A0A2T5B817_958 1-66 10-74 0.96 0.82 0.76 0.67 0.67 0.76 22.7
O43663_2001421 MC9534 A0A6A3CW71_9534 9-448 30-346 0.98 0.88 0.24 0.29 0.29 0.58 16.7
Q9BQ65_2000857 MC9528 A0A2J8VZJ9_9528 1-182 10-191 0.97 0.95 0.97 0.95 0.95 0.98 97.2
P04070_2000651 MC9456 A0A218V611_9456 1-33 24-56 1.0 0.49 0.96 0.48 0.48 0.97 60.6
D6RDG8_2000649 MC9450 A0A7R8Z907_9450 1-138 9-146 1.0 0.88 1.0 0.88 0.88 1.0 95.6
O66465_2001391 MC9439 A0A379TFQ0_9439 12-337 2-328 0.95 0.99 0.92 0.96 0.96 0.87 47.4
Q7AKG9_2000844 MC9416 A0A7X6A0R4_9416 1-75 2-76 1.0 0.4 1.0 0.39 0.39 1.0 78.6
Q13825_2000027 MC9389 A0A2K5NKM3_9389 1-173 21-193 1.0 0.82 1.0 0.82 0.82 1.0 98.8
Q62696_2000666 MC9379 A0A267FP46_9379 1-60 4-63 1.0 0.43 0.93 0.41 0.41 0.93 65.0
Q8C6E0_2001299 MC9337 A0A402F1A5_9337 5-123 2-120 0.93 0.98 0.92 0.98 0.98 0.97 86.5
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.