DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P45906_2000726 MC8897 A0A0C2N7T9_8897 1-55 2-62 0.86 0.43 0.48 0.24 0.24 0.71 11.4
P30440_2000609 MC8883 A0A7J7M8T0_8883 5-72 10-86 0.94 0.37 0.43 0.19 0.19 0.6 8.4
Q8TCG5_2000102 MC8883 A0A6A1USJ0_8883 8-50 149-191 0.86 0.22 0.62 0.18 0.18 0.83 16.2
Q2ACK9_2001374 MC8843 A0A6J1W6J2_8843 1-53 1-46 0.98 0.18 0.42 0.09 0.09 0.77 3.7
O75324_2001380 MC8824 A0A8B6F172_8824 1-75 21-90 0.85 0.23 0.48 0.16 0.16 0.75 13.1
P60896_2001328 MC8818 B2RYD1_8818 1-57 186-242 0.98 0.2 0.32 0.09 0.09 0.77 12.2
P09546_2000855 MC8818 A0A7I8VTP8_8818 1-171 162-272 0.98 0.36 0.12 0.08 0.08 0.52 8.7
P83789_2001372 MC8781 A0A1V5HTV5_8781 24-152 2-130 0.81 0.98 0.8 0.97 0.97 0.81 51.1
O76095_2000370 MC8764 A0A672UY80_8764 1-57 28-84 0.98 0.45 0.96 0.45 0.45 0.98 66.6
Q15758_2001088 MC8736 H3FCU9_8736 82-445 3-366 0.82 0.96 0.77 0.91 0.91 0.76 39.8
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.