DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q96A72_2000417 MC58412 A0A2P6U2Y5_58412 2-135 3-136 0.93 0.98 0.93 0.98 0.98 0.95 81.3
O75084_2001193 MC5840 A0A4Z2CG33_5840 1-116 13-128 1.0 0.82 1.0 0.82 0.82 0.99 93.9
Q7Z7E8_2000386 MC5837 A0A669P4I5_5837 1-158 5-162 1.0 0.94 1.0 0.93 0.93 1.0 87.3
G8JZS6_2001350 MC5832 A0A7V1AQA6_5832 2-102 13-110 0.99 0.88 0.69 0.64 0.64 0.59 23.3
P83772_2000305 MC58172 A0A6N9QBA3_58172 17-250 3-233 0.91 0.99 0.85 0.94 0.94 0.8 37.6
P31742_2001250 MC5812 A0A1W1HBV9_5812 3-60 75-138 0.95 0.36 0.81 0.31 0.31 0.84 12.5
Q9HVV7_2001334 MC58115 A0A0K6IPF3_58115 1-145 13-158 1.0 0.92 0.91 0.84 0.84 0.85 25.0
W1DN50_2000980 MC58107 A0A1H4IA45_58107 2-259 7-269 0.99 0.98 0.97 0.94 0.94 0.89 40.3
O13828_2000815 MC58027 A0A0D0D6A2_58027 3-93 23-113 0.97 0.53 0.94 0.52 0.52 0.91 61.5
Q245F2_2000419 MC57890 A0A821LI74_57890 1-225 1-225 1.0 0.99 0.99 0.98 0.98 0.97 68.0
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.