DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q8ZKJ0_2001171 MC59165 A0A4R6U5E4_59165 5-134 2-133 0.97 0.94 0.9 0.86 0.86 0.8 23.3
P79073_2001113 MC5901 A0A5P8PBG7_5901 1-68 25-91 0.97 0.74 0.94 0.72 0.72 0.93 55.8
P37487_2000561 MC59001 W1VFD5_59001 2-187 3-190 1.0 0.8 0.98 0.78 0.78 0.94 58.5
P14900_2000079 MC58858 K8AVJ7_58858 1-134 237-370 0.98 0.36 0.98 0.36 0.36 0.98 86.5
P0C7U7_2000189 MC58844 A0A5K3ENZ0_58844 22-294 535-704 0.92 0.2 0.35 0.12 0.12 0.51 9.1
P81511_2000643 MC588 A0A1Q9DA36_588 2-60 21-90 0.97 0.78 0.51 0.38 0.38 0.46 5.4
O95273_2000829 MC58767 A0A6B0RF32_58767 5-153 2-149 0.97 0.45 0.93 0.44 0.44 0.92 79.8
O75146_2000838 MC58767 A0A7J8EZ52_58767 1-194 150-343 1.0 0.54 0.98 0.53 0.53 0.97 70.6
Q9YAS7_2000604 MC5865 A0A832FZ85_5865 1-94 2-95 1.0 0.82 0.99 0.81 0.81 0.99 57.4
O26773_2000748 MC5864 A0A7C0UTR1_5864 13-85 2-75 0.8 0.97 0.75 0.89 0.89 0.77 16.2
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.