DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
D9N551_2000446 MC57838 A0A7X1GZI5_57838 1-86 36-123 0.99 0.6 0.65 0.4 0.4 0.64 12.3
P0A0V1_2001528 MC57838 A0A2J6IWD1_57838 1-129 34-163 0.99 0.79 0.7 0.56 0.56 0.67 17.8
P74881_2001065 MC57823 A0A3S4FKK0_57823 1-200 207-406 1.0 0.37 1.0 0.37 0.37 1.0 99.5
P41409_2000765 MC57714 A0A077ZH25_57714 1-297 5-301 0.96 0.99 0.96 0.99 0.99 0.96 99.6
Q8R910_2000096 MC5768 A0A538SZH3_5768 2-85 11-94 0.99 0.88 0.97 0.86 0.86 0.95 47.6
Q9NTX7_2000763 MC57600 A0A836AK00_57600 1-85 1-85 1.0 0.98 0.99 0.97 0.97 0.98 96.4
A8HBN5_2001326 MC57584 A0A0S6XIF9_57584 4-155 126-277 0.98 0.48 0.91 0.46 0.46 0.84 19.3
Q05193_2001264 MC57550 A0A060YH83_57550 1-54 26-79 0.96 0.44 0.86 0.41 0.41 0.92 38.8
P83789_2001373 MC57519 A0A1V5HTV5_57519 1-226 33-257 0.99 0.87 0.97 0.87 0.87 0.95 60.1
Q7WTC8_2001443 MC57499 A0A0B3BTE9_57499 22-136 4-118 0.81 0.97 0.53 0.62 0.62 0.54 15.7
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.