DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q9RFC8_2001563 MC6116 F9Y7U2_6116 8-150 2-144 0.91 0.99 0.9 0.98 0.98 0.89 46.1
Q7LFL8_2001313 MC61146 A0A401RZP9_61146 1-44 84-127 1.0 0.3 0.99 0.3 0.3 1.0 90.9
Q58988_2000618 MC611 A0A1F9ZG16_611 2-83 3-84 0.99 0.98 0.96 0.95 0.95 0.95 47.5
Q6MZP7_2001265 MC61091 A0A803LBS1_61091 1-47 111-157 1.0 0.24 0.99 0.24 0.24 0.99 70.2
Q9U966_2000458 MC6103 E9GE65_6103 3-67 36-109 0.87 0.67 0.74 0.52 0.52 0.74 19.7
X6Q997_2001165 MC61020 A0A2Z6IJ65_61020 25-328 3-304 0.84 0.99 0.82 0.97 0.97 0.82 54.9
W8YSI5_2000220 MC60924 A0A2V9BPY0_60924 3-291 1-295 0.98 1.0 0.96 0.96 0.96 0.89 50.8
Q03529_2001423 MC60779 A8JGN3_60779 36-257 1-159 0.83 1.0 0.53 0.88 0.88 0.55 27.8
Q9UWW1_2001162 MC60704 A0A662SM16_60704 3-206 1-193 0.99 0.62 0.72 0.5 0.5 0.63 21.4
Q8IDI8_2000596 MC60572 A0A6V7XWF2_60572 4-156 2-157 0.98 0.99 0.89 0.89 0.89 0.81 21.0
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.