DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P53620_2000291 MC61388 A0A524Q8G4_61388 2-100 110-206 0.88 0.47 0.68 0.39 0.39 0.61 10.8
A6KZN2_2001046 MC61388 A0A2W2BE25_61388 13-98 2-89 0.88 0.47 0.69 0.39 0.39 0.72 11.1
P80386_2000327 MC61388 A0A7S0JSC1_61388 6-84 137-216 0.94 0.36 0.81 0.33 0.33 0.88 38.2
P83040_2000321 MC61388 A0A0P6XT77_61388 3-97 14-99 0.94 0.57 0.57 0.41 0.41 0.52 11.8
Q6NEZ3_2000217 MC61388 A0A6J7F0F2_61388 1-170 36-198 1.0 0.52 0.61 0.37 0.37 0.49 13.6
P14768_2000636 MC61388 A0A4Q5VFX7_61388 3-49 174-220 0.96 0.18 0.92 0.18 0.18 0.93 65.9
Q15022_2001433 MC61245 A0A2T7Q0Q3_61245 1-127 92-218 0.99 0.57 0.98 0.57 0.57 0.97 51.9
Q87WW1_2000004 MC61195 A0A0P9IV70_61195 1-105 105-209 1.0 0.49 1.0 0.49 0.49 1.0 99.0
P49410_2000073 MC61195 F1RFI1_61195 1-87 17-103 1.0 0.43 1.0 0.43 0.43 1.0 98.8
A0A031LXI5_2000900 MC61164 A0A7J6ZC79_61164 1-294 16-309 1.0 0.8 1.0 0.8 0.8 1.0 87.7
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.