DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P16370_2000923 MC6191 C0NSH0_6191 2-131 40-170 0.99 0.49 0.97 0.48 0.48 0.95 58.7
Q8X5N8_2000262 MC6186 A0A7G2IUC1_6186 2-162 187-347 0.99 0.46 0.99 0.46 0.46 0.99 85.7
Q9BZR6_2000631 MC61848 A0A340XLE8_61848 4-257 1-254 0.89 1.0 0.89 1.0 1.0 0.94 91.7
Q9Y5J7_2000293 MC61829 A0A5N5N480_61829 1-73 14-86 1.0 0.81 0.96 0.78 0.78 1.0 93.1
P81040_2000127 MC61789 A0A101G0J9_61789 1-168 1-142 0.98 0.99 0.65 0.77 0.77 0.6 15.2
Q5N8J1_2001440 MC61588 A0A3L6SSF8_61588 1-88 123-210 0.99 0.41 0.99 0.41 0.41 0.99 85.2
P39958_2000035 MC61525 A0A2M7DLM9_61525 5-96 344-435 0.9 0.21 0.57 0.17 0.17 0.49 14.5
P03915_2001368 MC61525 A0A7T6ZQV3_61525 1-165 55-219 0.99 0.65 0.99 0.65 0.65 0.99 72.1
Q9TZ51_2001486 MC614 G0N4R0_614 2-134 5-137 0.96 0.96 0.96 0.96 0.96 0.94 87.2
Q31164_2000357 MC61388 A0A3Q3G7S0_61388 1-86 95-180 0.97 0.27 0.85 0.25 0.25 0.76 13.9
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.