DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q9S1H5_2000128 MC694 A0A0N0Z660_694 2-129 1-128 0.99 0.98 0.98 0.98 0.98 0.96 50.7
Q7RXY1_2000624 MC6936 A0A178FEP3_6936 12-121 1-110 0.91 1.0 0.91 1.0 1.0 0.94 77.2
Q9YFY3_2000372 MC6918 U3TAV9_6918 1-135 1-135 0.99 1.0 0.99 1.0 1.0 0.99 82.2
P30533_2000771 MC6886 A0A6P6HQ51_6886 1-105 182-286 1.0 0.37 0.97 0.36 0.36 0.98 80.0
A5TZS3_2001243 MC6860 A0A1Y0BZA4_6860 1-89 1-89 0.89 0.99 0.84 0.93 0.93 0.84 64.0
Q8U919_2000942 MC6819 A0A7R9L6U8_6819 5-253 1-249 0.97 1.0 0.96 0.99 0.99 0.94 62.6
Q9QZQ1_2000121 MC6817 Q9QZQ1_6817 1-122 7-128 1.0 0.84 1.0 0.84 0.84 1.0 100.0
Q9UMS0_2000780 MC678 A0A5C6N1R9_678 1-95 2-96 0.98 0.99 0.96 0.97 0.97 0.95 64.2
Q9Y6Q9_2001174 MC6738 A0A5B9Z0Y7_6738 2-46 46-88 0.96 0.23 0.42 0.11 0.11 0.7 15.2
P23318_2000547 MC6733 A0A0R0BQT2_6733 2-56 6-53 0.93 0.21 0.57 0.17 0.17 0.64 16.3
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.