DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q3HNM7_2001524 MC7128 A0A2D6N2S1_7128 2-17 554-569 0.94 0.03 0.74 0.03 0.03 0.91 6.2
Q12000_2001481 MC7107 A0A3P8Y3U3_7107 13-115 39-137 0.84 0.46 0.2 0.11 0.11 0.6 13.1
Q8N488_2000139 MC7089 A0A2W1BKW9_7089 1-32 59-90 1.0 0.3 0.96 0.3 0.3 0.99 62.5
P38445_2000373 MC7088 S7QA92_7088 1-93 2-94 1.0 0.93 0.99 0.92 0.92 0.98 100.0
Q1XA76_2001643 MC7086 A0A498MKZ5_7086 38-353 1-315 0.9 0.88 0.89 0.88 0.88 0.87 75.9
Q86BW2_2000298 MC7057 A0A3R7N8X7_7057 5-88 16-90 0.92 0.36 0.41 0.23 0.23 0.52 4.7
Q9JM76_2001117 MC7050 S7PZF8_7050 3-150 1-148 0.83 1.0 0.83 1.0 1.0 0.9 97.9
Q96IV0_2000924 MC7044 A0A2I3TIP9_7044 1-99 5-103 1.0 0.83 1.0 0.83 0.83 1.0 100.0
O34588_2001014 MC6965 Q6HEH9_6965 1-76 1-75 0.97 0.99 0.94 0.96 0.96 0.93 63.1
Q9HL76_2000752 MC6941 A0A3D1G1E4_6941 1-51 101-148 0.96 0.29 0.66 0.25 0.25 0.65 7.8
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.