DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q3E7C1_2000473 MC6688 C4YC80_6688 1-62 2-63 0.98 0.98 0.97 0.97 0.97 0.97 64.5
Q8ZKB0_2001263 MC6677 A0A6A5KSZ2_6677 1-59 156-214 0.98 0.26 0.98 0.26 0.26 0.98 89.8
Q9WZM6_2001262 MC6677 A0A7V4KBL2_6677 1-88 75-161 0.95 0.54 0.9 0.53 0.53 0.89 51.1
Q9HAU5_2001402 MC6646 A0A1I8I7B6_6646 1-93 72-167 0.99 0.34 0.27 0.1 0.1 0.57 14.8
Q9DCJ5_2000175 MC6621 A0A7M7GGU2_6621 1-58 14-71 1.0 0.44 1.0 0.44 0.44 1.0 63.7
P28234_2001093 MC6557 L8HGR2_6557 16-105 265-354 0.86 0.24 0.2 0.07 0.07 0.83 12.2
Q13625_2000134 MC6557 E2B3N9_6557 1-130 16-145 1.0 0.89 1.0 0.89 0.89 0.99 70.0
P62495_2001202 MC6550 A0A812YQS6_6550 1-129 1-129 0.94 1.0 0.92 0.99 0.99 0.92 67.4
Q53HL2_2001361 MC6521 A0A0N1I5A4_6521 4-55 129-184 0.91 0.3 0.64 0.23 0.23 0.69 16.0
P0AES4_2001101 MC6474 A0A0G0VKC6_6474 2-355 62-432 0.98 0.86 0.84 0.7 0.7 0.86 40.3
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.