DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P04233_2000699 MC7254 A0A1D6KXE9_7254 2-74 183-248 0.97 0.24 0.34 0.11 0.11 0.66 12.3
P82243_2001645 MC7227 A0A2E6H974_7227 2-46 45-90 0.96 0.2 0.62 0.16 0.16 0.68 17.0
P67876_2001128 MC7179 P0CL71_7179 1-148 27-174 0.99 0.85 0.99 0.85 0.85 0.99 84.4
Q5MJ80_2001451 MC7176 A0A3S4EWH5_7176 1-31 7-37 0.97 0.23 0.96 0.23 0.23 0.97 80.6
P23862_2001503 MC7169 A0A158P9C8_7169 2-97 23-119 0.98 0.56 0.67 0.4 0.4 0.63 9.5
O66728_2000808 MC7162 A0A2V6R644_7162 3-211 230-496 0.97 0.35 0.72 0.24 0.24 0.57 13.7
Q13951_2000741 MC715 A0A673JVB9_715 1-137 4-140 0.99 0.87 0.97 0.85 0.85 0.96 92.7
Q9LUJ3_2000877 MC7145 A0A6N2B8Z0_7145 1-118 2-119 0.98 0.99 0.94 0.96 0.96 0.92 54.2
Q8IYD8_2001539 MC7143 A0A6V7VVZ2_7143 5-100 17-116 0.83 0.66 0.16 0.12 0.12 0.5 11.0
Q01973_2000492 MC7132 A0A671L5Q7_7132 1-80 9-88 1.0 0.85 1.0 0.85 0.85 1.0 77.5
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.