DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
W2EQT0_2001430 MC10544 A0A381GPH6_10544 1-91 1-99 0.99 1.0 0.81 0.76 0.76 0.74 20.7
Q81EU2_2000964 MC10461 A0A3B8VPF2_10461 1-95 7-114 0.99 0.93 0.82 0.69 0.69 0.71 14.6
P06609_2000362 MC10405 A0A6A5KV39_10405 14-304 3-293 0.9 0.99 0.88 0.97 0.97 0.92 76.2
P0AEB2_2001233 MC10404 A0A1A9Z0V1_10404 2-93 67-158 0.99 0.54 0.96 0.54 0.54 0.95 44.5
Q04211_2000720 MC10389 A0A2U3VEF2_10389 2-118 1-117 0.99 0.85 0.99 0.85 0.85 0.99 97.4
C5DEB9_2001444 MC10354 A0A4S2N4B9_10354 1-101 41-158 0.95 0.45 0.61 0.27 0.27 0.64 14.3
P47736_2001205 MC1034 A0A2D0STQ3_1034 3-336 8-341 0.99 0.94 0.98 0.92 0.92 0.94 69.7
W5P642_2000511 MC10313 A0A674A4G1_10313 2-105 13-116 0.99 0.9 0.99 0.89 0.89 0.99 76.9
Q8RSY1_2001285 MC10280 A0A834DN21_10280 2-78 21-112 0.99 0.44 0.61 0.28 0.28 0.59 4.3
O60678_2001329 MC10263 A0A0F9HB00_10263 3-147 5-105 0.85 0.96 0.36 0.53 0.53 0.39 8.0
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.