DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q9QUH6_2000738 MC10952 L9L780_10952 1-148 41-188 1.0 0.46 1.0 0.46 0.46 1.0 100.0
Q830X4_2001187 MC10951 A0A077ZBW2_10951 5-297 2-294 0.99 0.97 0.91 0.89 0.89 0.88 59.0
P22579_2000337 MC10822 A0A5D3DIK1_10822 1-71 4-74 1.0 0.82 0.96 0.79 0.79 0.94 29.5
Q8WXH5_2000638 MC10763 A0A0R3PZ68_10763 1-38 42-79 0.86 0.48 0.86 0.48 0.48 0.97 55.2
Q53WG8_2001317 MC1074 A0A497BFW7_1074 1-254 3-257 0.87 0.99 0.85 0.96 0.96 0.89 58.0
P02920_2000248 MC10731 A0A3S4KEY5_10731 5-402 10-407 0.95 0.98 0.94 0.96 0.96 0.92 61.0
Q92665_2000650 MC1069 A0A1S3GVC7_1069 1-57 18-74 1.0 0.7 1.0 0.7 0.7 1.0 92.9
P00733_2000821 MC10667 A0A6M1QUX1_10667 1-83 35-117 1.0 0.51 0.99 0.5 0.5 0.97 71.0
P47998_2000873 MC10663 A0A6D2I0R9_10663 14-306 1-293 0.92 1.0 0.91 1.0 1.0 0.97 90.1
Q9JHW2_2000690 MC10626 A0A091DV55_10626 6-248 2-244 0.89 0.99 0.89 0.99 0.99 0.96 93.0
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.