DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q13330_2001601 MC7388 A0A3P8W2D7_7388 1-17 174-190 0.85 0.07 0.69 0.06 0.06 0.79 11.7
P39935_2000823 MC7384 W7M0L4_7384 2-98 22-100 0.99 0.24 0.16 0.08 0.08 0.51 12.7
P26446_2000232 MC7378 E1VAZ0_7378 2-122 1-111 0.9 1.0 0.46 0.53 0.53 0.47 10.7
P17737_2000630 MC7370 A0A2S1YHH6_7370 1-50 40-105 0.98 0.6 0.62 0.33 0.33 0.59 12.1
Q9V2K7_2001319 MC737 A0A146K5I0_737 30-188 1-170 0.85 0.98 0.8 0.87 0.87 0.78 24.1
Q60634_2000570 MC737 A0A672LPM1_737 2-130 40-168 0.98 0.57 0.98 0.57 0.57 0.99 89.1
Q9D8T0_2001375 MC7355 A0A340YCB4_7355 3-174 10-181 0.98 0.94 0.97 0.93 0.93 0.95 58.7
Q7MUU3_2000952 MC735 A0A2A6E6L3_735 4-195 12-200 0.98 0.94 0.88 0.87 0.87 0.79 32.8
O31947_2000615 MC7320 A0A817T2A3_7320 1-62 60-107 1.0 0.35 0.36 0.2 0.2 0.58 12.9
P10026_2000807 MC7295 A0A6V7VNW6_7295 3-58 241-291 0.82 0.13 0.36 0.07 0.07 0.66 19.6
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.