DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q50EL4_2000774 MC15897 A0A7S0SKC3_15897 1-208 7-212 1.0 0.97 0.98 0.96 0.96 0.95 61.5
Q9I585_2000809 MC15859 A0A656H0B2_15859 2-136 4-138 0.97 0.91 0.86 0.82 0.82 0.97 71.1
A5Z9E1_2001629 MC15850 A0A416NG83_15850 2-88 16-102 0.97 0.72 0.91 0.69 0.69 0.87 27.5
Q6B856_2001082 MC15822 A0A0G4IUJ2_15822 1-242 138-379 1.0 0.43 1.0 0.43 0.43 0.99 90.0
Q9KN50_2001354 MC15792 A0A1Y5GZ86_15792 1-159 14-172 0.99 0.69 0.97 0.68 0.68 0.92 35.8
P15289_2000817 MC15757 A0A7J8JAC8_15757 1-326 4-329 1.0 0.76 1.0 0.76 0.76 1.0 88.3
Q9ZMW8_2001118 MC15660 C4GF74_15660 9-145 1-137 0.91 1.0 0.91 0.99 0.99 0.93 64.2
Q976G0_2000851 MC15647 A0A2H5W4W0_15647 19-202 2-172 0.82 0.99 0.71 0.92 0.92 0.75 41.6
Q9RTP8_2001010 MC15600 A0A1B2HV55_15600 2-384 5-384 0.99 0.98 0.97 0.97 0.97 0.9 51.1
P11741_2001037 MC15510 A0A7V1Q5B7_15510 5-360 2-158 0.99 0.99 0.24 0.5 0.5 0.4 5.1
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.