DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
R4IT35_2001533 MC16419 A0A1G4JB89_16419 10-140 1-137 0.92 0.99 0.6 0.62 0.62 0.58 22.6
Q9Y4E8_2001206 MC16275 A0A2Y9R951_16275 4-116 1-113 0.94 1.0 0.93 0.99 0.99 0.95 98.2
Q9WZI6_2001158 MC16261 M6YAD6_16261 1-433 10-452 1.0 0.98 0.91 0.88 0.88 0.79 26.1
P10414_2000375 MC16256 A0A2W5NVJ0_16256 4-39 8-39 0.9 0.43 0.66 0.38 0.38 0.69 11.1
Q97WD0_2000701 MC16227 W7SN62_16227 6-204 24-222 0.97 0.55 0.46 0.27 0.27 0.58 17.5
Q8VYR7_2001535 MC16154 A0A835QWI7_16154 1-554 31-586 1.0 0.88 0.98 0.87 0.87 0.95 83.4
Q9QX73_2000506 MC16154 A0A8B6BT75_16154 14-191 3-175 0.88 0.45 0.74 0.41 0.41 0.73 26.8
Q5RBR1_2000530 MC16137 A0A6G0IML2_16137 1-107 10-115 1.0 0.63 0.97 0.62 0.62 0.95 71.0
O18734_2000736 MC16116 A0A1A8K1C7_16116 1-96 22-117 0.97 0.81 0.7 0.59 0.59 0.68 59.3
P06450_2000442 MC15992 A0A835RES1_15992 1-73 73-145 1.0 0.5 0.99 0.5 0.5 1.0 79.4
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.