DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P20839_2000093 MC7530 A0A287B6A4_7530 1-120 11-130 1.0 0.91 1.0 0.91 0.91 1.0 77.5
B0V7M7_2001417 MC7510 A0A8A3PHT7_7510 10-86 1-103 0.88 0.83 0.43 0.33 0.33 0.52 5.6
Q97E82_2000394 MC7508 A0A1V5ZIZ5_7508 19-235 1-219 0.92 0.99 0.9 0.95 0.95 0.85 42.0
Q9K082_2000343 MC7478 A0A6L5DCX7_7478 2-146 11-155 0.99 0.94 0.95 0.9 0.9 0.88 55.8
P56064_2001219 MC7467 T1U7D2_7467 1-115 117-231 0.95 0.5 0.95 0.49 0.49 0.95 93.9
P00816_2000985 MC7445 A0A1C6CYP9_7445 2-63 41-92 0.89 0.24 0.35 0.15 0.15 0.6 4.6
P46075_2001396 MC7445 A0A084Q8R4_7445 17-213 3-200 0.92 0.99 0.87 0.93 0.93 0.84 46.9
P11978_2001541 MC7431 A0A0C9X177_7431 23-150 30-200 0.84 0.7 0.2 0.13 0.13 0.53 6.7
Q5A0X8_2001631 MC7404 A0A0C3FTJ9_7404 12-103 8-90 0.83 0.31 0.55 0.24 0.24 0.49 30.1
P23326_2000508 MC7389 A0A2G3BJ60_7389 1-62 63-124 1.0 0.35 1.0 0.35 0.35 1.0 88.7
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.