DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P12004_2000501 MC1783 A0A2P6TFV8_1783 1-129 119-247 1.0 0.52 0.99 0.52 0.52 0.98 59.6
Q8XPF0_2000287 MC17829 B6GCR3_17829 2-77 35-109 0.99 0.69 0.92 0.66 0.66 0.87 21.0
P61024_2000249 MC17765 A0A1A9VDG8_17765 1-69 1-69 1.0 0.92 0.99 0.91 0.91 0.99 72.4
Q5FVI6_2001073 MC17756 A0A3R7C4L8_17756 3-348 4-350 0.92 0.99 0.9 0.96 0.96 0.91 57.3
Q13255_2000339 MC17741 A0A3P9DMP6_17741 1-263 20-282 1.0 0.75 0.99 0.74 0.74 0.97 77.1
Q5SDB0_2000336 MC17735 A0A090QJB9_17735 18-100 1-83 0.82 1.0 0.81 0.98 0.98 0.92 66.2
Q9R1P4_2000081 MC17672 A0A2T7P4Y9_17672 14-230 1-217 0.91 1.0 0.91 0.99 0.99 0.94 74.1
Q9Y3B1_2000457 MC1744 A0A1A8A953_1744 2-170 1-169 0.99 0.97 0.97 0.95 0.95 0.94 81.0
Q8WWY3_2000954 MC17429 A0A814S790_17429 2-248 26-276 0.99 0.81 0.82 0.67 0.67 0.8 26.3
Q8U561_2001109 MC17399 A0A0C6FVM5_17399 1-116 3-117 0.99 0.7 0.97 0.69 0.69 0.95 59.4
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.