DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
O29777_2000628 MC18402 A0A220XV70_18402 1-113 44-161 1.0 0.42 0.95 0.39 0.39 0.89 34.7
G0SH11_2000640 MC18302 A0A178C8M5_18302 1-129 37-165 1.0 0.78 1.0 0.78 0.78 1.0 80.6
P15692_2000626 MC18216 A0A2K5LFX1_18216 2-51 23-72 0.98 0.69 0.94 0.67 0.67 0.94 100.0
Q9SCL7_2000796 MC18212 A0A2T8KX33_18212 1-262 13-274 1.0 0.96 0.99 0.95 0.95 0.98 71.3
Q8SQS4_2000918 MC1821 G3QRR7_1821 1-131 1-132 1.0 0.44 0.95 0.43 0.43 0.87 34.0
P09193_2001025 MC18132 A0A3N6PHH4_18132 3-424 1-313 0.95 0.99 0.67 0.94 0.94 0.87 43.0
Q8Y4N7_2000676 MC18116 A0A3D8TLE9_18116 1-155 1-155 0.98 1.0 0.97 1.0 1.0 0.99 87.7
Q9CXI5_2001161 MC1811 A0A444U674_1811 1-40 37-76 1.0 0.49 0.98 0.48 0.48 0.97 62.5
Q9LW31_2000197 MC18020 A0A2P5FCD9_18020 1-106 35-140 1.0 0.68 1.0 0.68 0.68 1.0 80.1
P9WMB9_2000063 MC17838 A0A2U3NFE9_17838 1-144 31-174 0.99 0.83 0.98 0.82 0.82 0.98 88.1
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.