DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
A9CIG4_2001242 MC18709 A0A849QP20_18709 5-93 17-121 0.88 0.87 0.65 0.56 0.56 0.65 17.1
O76054_2000944 MC18709 A0A6I9K6R2_18709 8-111 2-105 0.87 0.99 0.85 0.96 0.96 0.9 73.0
Q59290_2000064 MC18709 A0A494XE53_18709 1-192 8-199 1.0 0.96 0.98 0.95 0.95 0.98 69.7
P07222_2000578 MC18709 V4AWG8_18709 1-104 6-116 0.99 0.94 0.93 0.83 0.83 0.87 31.2
Q43125_2000589 MC18508 A0A3Q7H047_18508 1-292 163-454 0.97 0.64 0.97 0.64 0.64 0.98 90.7
Q43125_2001005 MC18508 A0A6A6LFA7_18508 2-184 5-187 0.99 0.56 0.99 0.56 0.56 0.98 81.4
Q9K706_2001126 MC18486 A0A7X8JDR5_18486 50-310 2-265 0.84 0.98 0.82 0.94 0.94 0.78 46.7
Q9US45_2001467 MC18475 A0A2S5B5N3_18475 1-111 3-118 0.99 0.52 0.94 0.48 0.48 0.9 38.7
Q9NRY2_2001295 MC1845 A0A6A4PFS8_1845 2-38 43-80 0.95 0.45 0.8 0.4 0.4 0.8 31.5
Q9UHY7_2001153 MC18402 T1DP55_18402 7-253 2-244 0.98 1.0 0.92 0.96 0.96 0.9 46.9
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.