DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P22635_2000516 MC19548 A0A062VP45_19548 16-126 1-111 0.84 1.0 0.83 0.99 0.99 0.91 63.0
Q9HTY8_2001198 MC19489 A0A1V3XEL0_19489 27-324 2-302 0.92 0.75 0.87 0.71 0.71 0.88 50.9
O29102_2000529 MC19433 A0A662P4M3_19433 2-76 4-77 0.99 0.78 0.93 0.75 0.75 0.86 28.0
Q62165_2000853 MC19413 W6KWG0_19413 7-109 2-88 0.82 0.98 0.39 0.5 0.5 0.42 6.3
P05106_2000525 MC19359 A0A556V851_19359 1-85 426-510 1.0 0.15 0.97 0.15 0.15 0.96 64.7
O75366_2000776 MC19322 A0A1Z5JY35_19322 1-36 49-84 1.0 0.43 0.99 0.43 0.43 1.0 41.6
Q833H6_2001530 MC19120 A0A1L8RGQ3_19120 21-159 2-136 0.87 0.99 0.81 0.95 0.95 0.85 51.7
P9WGP5_2000799 MC19049 A0A7X8VJ51_19049 1-217 23-239 0.99 0.91 0.95 0.87 0.87 0.91 57.6
P10408_2000345 MC19049 A0A6L5DCT4_19049 1-22 116-137 1.0 0.16 0.98 0.16 0.16 1.0 90.9
Q01770_2001178 MC18992 A0A644YZ20_18992 1-154 94-247 0.99 0.62 0.99 0.62 0.62 0.99 87.0
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.