DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
O96910_2001036 MC22361 B2B3Q6_22361 6-57 122-173 0.9 0.3 0.73 0.27 0.27 0.78 1.9
P29083_2001587 MC2236 A0A3R7NLL0_2236 1-61 13-91 0.98 0.35 0.48 0.16 0.16 0.64 13.7
Q12824_2001382 MC2236 A0A4Z2BL62_2236 1-67 20-86 1.0 0.31 1.0 0.31 0.31 1.0 91.0
Q57261_2001498 MC22358 A0A523Q8J6_22358 14-336 2-301 0.95 0.99 0.84 0.94 0.94 0.8 36.1
Q9HXB1_2000477 MC22352 A0A1G6WSM0_22352 1-123 16-142 0.95 0.89 0.69 0.63 0.63 0.65 19.0
Q12287_2000795 MC22295 A0A5P2UEX6_22295 1-65 1-64 0.94 1.0 0.59 0.64 0.64 0.86 61.5
W5QE72_2000395 MC22270 A0A3B5PYZ4_22270 1-49 26-74 1.0 0.64 0.99 0.64 0.64 1.0 57.1
P0AAB4_2000267 MC22205 A0A813Q3Q4_22205 1-163 1-163 0.98 0.99 0.94 0.95 0.95 0.96 68.7
O32054_2001194 MC22167 A0A3R6MXW2_22167 21-338 2-318 0.94 1.0 0.92 0.98 0.98 0.89 58.1
Q9Z621_2000304 MC22111 A0A4R4D5Y2_22111 2-67 25-90 0.94 0.72 0.85 0.67 0.67 0.83 33.3
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.