DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q8CLE0_2000392 MC2697 A0A495G1N5_2697 1-148 2-146 0.97 0.99 0.93 0.96 0.96 0.93 45.9
O24891_2001431 MC26864 A0A812KBB1_26864 2-229 338-624 0.99 0.43 0.63 0.24 0.24 0.49 11.7
Q9Y530_2000331 MC26862 A0A6L5DG47_26862 1-139 7-145 0.99 0.85 0.98 0.84 0.84 0.92 39.5
Q9W1H5_2001437 MC2686 A0A350WYY5_2686 3-36 4-37 0.94 0.09 0.84 0.09 0.09 0.92 17.6
P77918_2000848 MC2686 A0A226EVR5_2686 1-151 255-404 0.96 0.37 0.93 0.36 0.36 0.89 48.3
O66375_2000969 MC2686 O66375_2686 2-385 3-386 1.0 1.0 1.0 0.99 0.99 1.0 100.0
Q29075_2000403 MC26855 A0A5G2QNK4_26855 1-78 49-126 1.0 0.6 0.99 0.6 0.6 0.98 100.0
Q7MEA1_2000468 MC26621 A0A090S7X4_26621 2-140 1-139 0.91 1.0 0.9 0.99 0.99 0.89 70.5
Q9BT73_2001339 MC2660 A0A1V4KS98_2660 2-122 1-121 0.99 0.99 0.94 0.94 0.94 0.95 70.2
O13881_2001303 MC26583 A0A1Y2FQ62_26583 2-170 36-138 0.84 0.72 0.48 0.66 0.66 0.76 17.1
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.