DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
O34596_2000663 MC27423 A0A4U7JBU4_27423 4-144 2-141 0.93 0.97 0.89 0.93 0.93 0.88 34.5
U6GSR1_2000389 MC27384 A0A1C3GHU4_27384 10-230 1-221 0.96 0.9 0.96 0.9 0.9 0.97 95.9
P02721_2001215 MC27322 A0A2I4D6T2_27322 1-66 11-76 1.0 0.82 0.72 0.61 0.61 0.91 46.9
Q79VD7_2000424 MC27300 W7V9Y7_27300 33-534 2-503 0.88 1.0 0.87 1.0 1.0 0.96 66.3
Q8ZME0_2000711 MC27154 A0A7V3ADP1_27154 45-372 1-334 0.86 1.0 0.8 0.9 0.9 0.8 44.4
A0A067YSJ2_2000947 MC27145 P30943_27145 1-67 38-104 1.0 0.64 1.0 0.64 0.64 1.0 82.0
P9WNF5_2001018 MC271 A0A7I7UTW6_271 29-161 1-134 0.82 1.0 0.81 0.99 0.99 0.9 70.1
P40955_2001272 MC27044 F2UD15_27044 11-168 4-164 0.88 0.98 0.72 0.78 0.78 0.64 20.3
Q12114_2001561 MC2703 A0A4U0WLC1_2703 2-51 15-64 0.98 0.56 0.96 0.56 0.56 0.97 46.0
Q93VA3_2000521 MC26980 A0A4V6A823_26980 1-102 14-115 1.0 0.86 0.99 0.86 0.86 0.99 88.2
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.