DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q63KH5_2001107 MC27931 A0A3B6WHM1_27931 5-249 2-246 0.98 1.0 0.98 1.0 1.0 0.99 100.0
P54274_2000213 MC27886 A0A2I3I0I1_27886 1-203 24-188 1.0 0.52 0.66 0.44 0.44 0.65 64.7
Q96EB6_2001062 MC27878 A0A1U8D6G2_27878 1-268 2-269 0.98 1.0 0.98 0.99 0.99 0.99 95.8
Q92M60_2001137 MC27843 A0A7Y9P8K4_27843 3-78 1-76 0.96 0.88 0.95 0.88 0.88 0.97 68.4
Q3M6F6_2000176 MC27733 A0A0N0V037_27733 1-99 1-99 0.89 1.0 0.87 0.97 0.97 0.88 42.4
Q5SHE9_2000732 MC27725 A0A2G3DID2_27725 2-76 56-131 0.99 0.51 0.86 0.46 0.46 0.76 23.6
P01535_2000463 MC2771 A0A383W7M8_2771 4-26 28-50 0.85 0.2 0.51 0.16 0.16 0.61 30.4
Q8I2F2_2001425 MC27674 W4J477_27674 1-148 37-184 0.99 0.78 0.61 0.48 0.48 0.95 100.0
Q60C73_2001476 MC27480 A0A2Z7DCN2_27480 2-62 109-176 0.97 0.35 0.89 0.3 0.3 0.87 8.8
Q9M3M6_2000349 MC27452 A0A6M5U9X3_27452 1-61 16-76 1.0 0.8 0.99 0.79 0.79 0.99 93.4
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.