DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q9H4G4_2000347 MC28435 S9Y3S5_28435 5-140 2-137 0.91 0.99 0.91 0.99 0.99 0.92 96.3
Q8CYK3_2001567 MC28403 A0A4J1ZJS1_28403 2-100 4-102 0.99 0.9 0.99 0.9 0.9 0.99 100.0
Q96PE7_2000478 MC28349 A0A814K0G1_28349 1-132 12-144 1.0 0.84 0.99 0.83 0.83 0.98 65.4
O06878_2000396 MC28320 I0FET7_28320 27-290 3-250 0.91 0.98 0.65 0.73 0.73 0.56 26.9
Q7DD77_2001479 MC28158 A0A1F3XTW0_28158 1-82 40-122 1.0 0.67 0.96 0.64 0.64 0.93 24.0
A7M5V0_2001275 MC2815 A0A644Z4M7_2815 5-131 1-127 0.93 1.0 0.92 0.99 0.99 0.94 66.9
O50954_2001324 MC28114 W5SW43_28114 2-209 44-242 1.0 0.82 0.85 0.74 0.74 0.78 19.9
P04414_2000466 MC28059 A0A6A4S0K1_28059 2-91 30-119 0.99 0.25 0.99 0.25 0.25 0.99 87.7
Q9XSC6_2000435 MC28059 A0A3M6TIG5_28059 2-268 126-392 0.96 0.68 0.95 0.68 0.68 0.93 71.1
Q9NR71_2000653 MC28048 A0A058Z6J8_28048 3-211 442-658 0.98 0.26 0.92 0.24 0.24 0.88 45.9
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.