DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P15289_2000300 MC30118 A0A7J8JBA0_30118 1-101 105-205 1.0 0.47 0.99 0.47 0.47 0.98 79.2
B2J5W7_2001589 MC30044 A0A3G6X2P5_30044 8-215 2-206 0.96 1.0 0.87 0.91 0.91 0.8 39.8
Q7SID2_2000600 MC3003 A0A852W5S5_3003 24-203 2-180 0.89 0.99 0.87 0.98 0.98 0.94 56.6
Q99538_2000698 MC29998 A0A813U4Q5_29998 1-261 5-267 0.99 0.98 0.99 0.97 0.97 0.97 63.4
O00459_2001019 MC29984 A0A6P8S8E2_29984 1-163 123-285 1.0 0.48 1.0 0.48 0.48 1.0 84.0
O59205_2000629 MC2995 D8LYT9_2995 2-141 3-144 0.99 0.99 0.92 0.9 0.9 0.84 26.5
O00401_2000436 MC29937 A0A3B4BIV8_29937 1-64 15-78 1.0 0.72 0.91 0.67 0.67 0.94 93.7
Q93ZE8_2000422 MC29884 A0A2N9GH29_29884 1-181 10-190 1.0 0.94 1.0 0.94 0.94 0.99 80.1
P12669_2001497 MC29883 M5R3K3_29883 6-132 10-132 0.96 0.93 0.88 0.88 0.88 0.83 43.3
Q9H900_2001447 MC29850 A0A671VQ32_29850 1-165 160-327 1.0 0.45 0.96 0.43 0.43 0.92 54.1
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.