DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q9UBT6_2000156 MC38120 A0A6I9KIH2_38120 1-105 279-383 1.0 0.21 1.0 0.21 0.21 1.0 93.3
Q9UJ41_2000991 MC38118 A0A6J1U8K5_38118 1-253 47-299 1.0 0.8 0.99 0.79 0.79 0.99 86.5
Q21121_2001560 MC38115 A0A813SQC0_38115 2-140 90-228 0.98 0.61 0.96 0.6 0.6 0.96 35.9
P69853_2000999 MC38110 A0A3S7DBF3_38110 17-196 2-181 0.88 0.99 0.88 0.99 0.99 0.9 76.1
A7LT28_2001348 MC38098 A0A845V950_38098 1-101 13-129 1.0 0.5 0.48 0.25 0.25 0.53 13.5
Q7SIG3_2000083 MC38098 L8Y6Z0_38098 1-235 6-241 1.0 0.97 0.99 0.96 0.96 0.98 67.7
P54342_2000582 MC38085 A0A1V6MSD7_38085 3-57 26-73 0.92 0.26 0.48 0.2 0.2 0.53 7.2
O26119_2001111 MC38005 A0A256Z792_38005 2-77 7-82 0.97 0.87 0.96 0.86 0.86 0.95 43.4
Q9ESU6_2001344 MC37849 P13709_37849 1-72 28-99 1.0 0.66 0.99 0.65 0.65 0.98 87.5
P05314_2000421 MC37826 B8AJ41_37826 1-171 70-239 1.0 0.62 0.99 0.62 0.62 0.98 76.0
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.