DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q02241_2001480 MC38678 A0A3P7MKG1_38678 7-101 13-110 0.93 0.89 0.82 0.76 0.76 0.8 36.7
V0YWY6_2000358 MC38658 A0A7G2II41_38658 1-104 131-234 0.99 0.44 0.99 0.44 0.44 0.99 94.2
Q87SQ4_2001079 MC38656 A0A3R8PHU7_38656 2-165 5-166 0.98 0.97 0.9 0.9 0.9 0.83 38.4
Q9U6B8_2001564 MC3865 A0A167PXT8_3865 1-179 28-254 0.94 0.72 0.62 0.41 0.41 0.63 9.9
Q8VDS3_2000141 MC38647 A0A250YDS2_38647 1-52 10-61 0.98 0.74 0.98 0.74 0.74 0.99 100.0
P40043_2001458 MC38335 A0A6V7VDD7_38335 6-140 1-100 0.92 0.98 0.39 0.52 0.52 0.43 8.2
Q71SY5_2000434 MC38248 A0A4Z2BYM1_38248 1-158 40-198 1.0 0.76 0.96 0.73 0.73 0.93 86.1
P01032_2000294 MC3821 A0A4X1UM89_3821 1-65 1-65 0.98 0.68 0.98 0.68 0.68 0.99 98.4
Q8BG62_2000634 MC3820 A0A2K6QP83_3820 1-51 6-56 1.0 0.63 0.86 0.56 0.56 0.93 39.2
Q0SI31_2000334 MC38144 A0A3L7W747_38144 6-159 2-154 0.93 0.99 0.86 0.91 0.91 0.79 25.6
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.