DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
B6WRT5_2001367 MC4038 B6WRT5_4038 1-118 19-136 1.0 0.62 1.0 0.62 0.62 1.0 100.0
P09372_2001011 MC40344 I6DUI9_40344 2-58 104-160 0.97 0.36 0.97 0.36 0.36 0.98 100.0
P0AFY8_2000423 MC40247 A0A7H4P7S9_40247 7-109 2-104 0.93 0.98 0.93 0.98 0.98 0.93 90.2
Q87WS9_2001103 MC40218 A0A7C5PTK5_40218 2-144 26-168 0.97 0.85 0.93 0.82 0.82 0.88 41.2
P69922_2000949 MC40208 A0A3A6JKB1_40208 56-355 1-306 0.84 0.95 0.82 0.91 0.91 0.84 55.8
J7RUA5_2001499 MC40200 A0A0R1WFV5_40200 3-170 38-227 0.99 0.57 0.91 0.47 0.47 0.84 33.5
Q6N5V5_2001545 MC4020 A0A523J5P6_4020 6-85 1-81 0.82 0.99 0.74 0.88 0.88 0.84 34.5
P0ABY7_2000961 MC4019 A0A231HLG2_4019 1-156 5-165 1.0 0.93 0.96 0.87 0.87 0.91 52.7
P61619_2000261 MC40158 J9BGP3_40158 44-435 1-389 0.85 1.0 0.83 0.98 0.98 0.88 86.9
A0R049_2000432 MC40149 C3JJ93_40149 1-180 1-180 0.98 1.0 0.98 1.0 1.0 0.97 87.7
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.