DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P0DJ55_2000731 MC46446 P0DJ55_46446 1-272 2-273 1.0 0.79 1.0 0.79 0.79 1.0 100.0
A7LT28_2001349 MC464 A0A656SET6_464 56-311 4-228 0.81 0.98 0.52 0.7 0.7 0.48 13.6
Q5BL07_2000467 MC46366 A0A402F5D3_46366 1-80 87-166 1.0 0.44 1.0 0.44 0.44 1.0 73.7
Q8E8X2_2000714 MC46361 A0A3S4HVJ9_46361 2-154 1-153 0.99 0.96 0.99 0.95 0.95 0.96 55.5
P47871_2000625 MC4633 A0A6J3QNF2_4633 1-98 11-108 1.0 0.73 0.99 0.72 0.72 0.99 95.9
Q9H7C9_2000472 MC46322 A0A7J7FHA8_46322 1-119 47-198 0.98 0.77 0.98 0.6 0.6 0.97 71.7
Q70GK9_2001196 MC46156 A0A4Y1ZCQ6_46156 1-106 47-157 1.0 0.71 0.91 0.63 0.63 0.83 24.1
Q70GK9_2000551 MC46156 A0A3M1LTI0_46156 22-183 2-141 0.88 0.72 0.72 0.69 0.69 0.7 26.3
Q8WUN7_2000733 MC46117 A0A094ZNJ3_46117 14-117 1-104 0.81 1.0 0.79 0.97 0.97 0.91 58.6
P91818_2000645 MC4609 A0A370BZC4_4609 2-61 31-91 0.82 0.65 0.61 0.48 0.48 0.66 19.0
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.