DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
O26496_2000696 MC8736 A0A0B6EQD9_8736 2-122 44-163 0.98 0.59 0.42 0.29 0.29 0.5 13.3
P32238_2000661 MC8733 A0A6V7UFT9_8733 2-47 38-75 0.98 0.16 0.29 0.07 0.07 0.69 6.5
Q13796_2001581 MC8726 Q09JY9_8726 2-169 41-208 0.99 0.78 0.99 0.78 0.78 1.0 79.1
P11274_2001105 MC8723 A0A1Y2GMB4_8723 5-66 115-170 0.92 0.16 0.58 0.12 0.12 0.77 16.1
Q9UBT2_2000122 MC8706 G3H7P3_8706 3-104 34-135 0.98 0.48 0.97 0.47 0.47 0.96 89.2
Q8TBC4_2000082 MC8706 A0A6A4SKF0_8706 1-61 60-120 1.0 0.24 1.0 0.24 0.24 1.0 95.0
O75129_2000413 MC8687 A0A6J3AFY8_8687 1-82 53-134 1.0 0.43 1.0 0.43 0.43 1.0 98.7
Q92608_2000831 MC8675 A0A4U5VMQ2_8675 1-81 73-153 1.0 0.12 0.98 0.12 0.12 0.98 71.6
P18418_2000388 MC8674 A0A085NTG2_8674 1-36 36-71 1.0 0.18 0.97 0.18 0.18 0.99 63.8
Q5QF96_2001209 MC8672 A0A835NII2_8672 29-335 2-308 0.89 0.99 0.89 0.99 0.99 0.95 66.7
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.