DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q9JVW4_2001403 MC53218 A0A1I4T0K3_53218 1-73 11-83 1.0 0.81 0.99 0.8 0.8 0.97 53.4
P0AAN1_2001622 MC53131 A0A2X2DL15_53131 14-144 2-132 0.81 0.99 0.75 0.92 0.92 0.83 64.8
Q9UM00_2001579 MC5312 A0A7R9A6D2_5312 6-173 3-170 0.97 0.94 0.93 0.91 0.91 0.9 67.2
O43765_2001135 MC53098 A0A7N9CZ94_53098 1-51 53-103 1.0 0.2 1.0 0.19 0.19 1.0 100.0
O32127_2001635 MC5303 D3FZ19_5303 2-91 3-92 0.99 0.88 0.98 0.88 0.88 0.99 66.6
Q5ZTF2_2001646 MC52813 A0A2T4VCS6_52813 14-86 3-75 0.84 0.91 0.75 0.81 0.81 0.76 46.5
A9CJ14_2000925 MC52676 A0A1J1IM24_52676 33-244 1-211 0.81 0.99 0.77 0.93 0.93 0.75 26.2
F6UME2_2001647 MC52602 A0A814IQI8_52602 36-322 2-256 0.88 0.94 0.73 0.88 0.88 0.7 19.3
Q60648_2000278 MC52595 A0A814KXC3_52595 2-162 12-178 0.99 0.94 0.82 0.75 0.75 0.74 26.3
Q92RG6_2000228 MC52595 A0A1Y1IAQ3_52595 13-127 2-116 0.88 0.99 0.86 0.97 0.97 0.89 50.4
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.