DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q8WV92_2000427 MC52481 A0A814HPN6_52481 1-154 17-172 1.0 0.91 0.98 0.88 0.88 0.93 50.6
P36068_2001241 MC52471 A0A182JTS1_52471 1-223 9-185 0.96 0.95 0.45 0.53 0.53 0.44 10.6
B8XX90_2001290 MC5220 A0A6I9ZE74_5220 1-186 15-200 1.0 0.89 0.99 0.88 0.88 0.98 87.0
P27362_2000960 MC52113 A0A0D9QSJ8_52113 4-406 1-403 0.97 1.0 0.97 1.0 1.0 0.97 89.8
Q9I4D6_2001091 MC52077 A0A4V3XGX9_52077 2-173 1-172 0.85 1.0 0.84 0.99 0.99 0.92 54.0
Q9M015_2000502 MC52046 A0A445AAW1_52046 26-164 1-126 0.82 0.99 0.61 0.81 0.81 0.74 20.2
Q55385_2001586 MC51999 A0A6B0ZXV1_51999 9-107 2-97 0.92 0.99 0.85 0.94 0.94 0.86 57.5
P10349_2000426 MC51995 A0A7Y2MTQ2_51995 39-330 24-243 0.8 0.9 0.39 0.54 0.54 0.37 15.9
P25655_2001413 MC51882 P25655_51882 6-147 2-143 0.96 0.56 0.96 0.56 0.56 0.97 100.0
Q9UQ26_2000296 MC51836 Q9UQ26_51836 1-118 4-121 1.0 0.84 1.0 0.84 0.84 1.0 100.0
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.