DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q8GS60_2001509 MC56421 A0A2P6VR10_56421 2-286 27-309 0.9 0.91 0.89 0.91 0.91 0.91 68.0
Q8U3S7_2000455 MC56419 A0A6P9F880_56419 1-82 1-82 0.91 1.0 0.83 0.9 0.9 0.78 23.1
Q9SUI4_2000553 MC56362 A0A833UBZ4_56362 1-153 2-154 0.96 0.99 0.96 0.99 0.99 0.97 88.8
Q9H444_2001376 MC56279 A0A5F8H1R5_56279 1-74 18-91 0.99 0.36 0.97 0.36 0.36 0.97 97.2
P9WH71_2001016 MC56013 A0A2M8VCU3_56013 1-282 25-306 1.0 0.92 1.0 0.92 0.92 0.99 81.9
Q8BH58_2001435 MC56010 A0A5F4CGU3_56010 6-217 1-212 0.86 1.0 0.82 0.95 0.95 0.86 98.5
Q5ZK43_2001508 MC55969 U3KHH5_55969 3-226 9-232 0.99 0.84 0.99 0.84 0.84 1.0 93.7
A0A330KW27_2000577 MC55884 D3PFJ7_55884 1-36 81-116 1.0 0.18 0.98 0.18 0.18 0.98 36.1
Q8DJY4_2001436 MC5574 A0A062SN03_5574 8-82 1-75 0.89 1.0 0.88 0.98 0.98 0.87 54.6
A9CHC6_2000694 MC55733 A0A5C8SVS6_55733 2-123 14-135 0.99 0.9 0.93 0.85 0.85 0.86 39.3
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.